Morbid obesity's impact on COVID-19 patients requiring venovenous extracorporeal membrane oxygenation: The covid-19 critical care consortium database review
Introduction: Obesity is associated with a worse prognosis in COVID-19 patients with acute respiratory distress syndrome (ARDS). Veno-venous (V-V) Extracorporeal Membrane Oxygenation (ECMO) can be a rescue option, however, the direct impact of morbid obesity in this select group of patients remains unclear.
Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19: An International COVID-19 Critical Care Consortium Study
Objectives: To determine the prevalence and outcomes associated with hemorrhage, disseminated intravascular coagulopathy, and thrombosis (HECTOR) complications in ICU patients with COVID-19.
Cerebrovascular Complications of COVID-19 on Venovenous Extracorporeal Membrane Oxygenation
Evidence of cerebrovascular complications in COVID-19 requiring venovenous extracorporeal membrane oxygenation (ECMO) is limited. Our study aims to characterize the prevalence and risk factors of stroke secondary to COVID-19 in patients on venovenous ECMO.
COV3: The Impact of Morbid Obesity on Patients with COVID-19 who Develop Respiratory Failure requiring Extracorporeal Membrane Oxygenation
In patients with COVID-19 and respiratory failure, class 3 obesity (body mass index > 40 kg/m2) has been associated with worse survival. Obese patients on mechanical ventilation with progressively more severe acute respiratory syndrome (ARDS) may be offered venovenous (VV) extracorporeal membrane oxygenation (ECMO) therapy. The impact of morbid obesity on the outcome of COVID-19 patients supported with VV ECMO has been underexplored.
Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis
Neurological and neuropsychiatric symptoms that persist or develop three months after the onset of COVID-19 pose a significant threat to the global healthcare system. These symptoms are yet to be synthesized and quantified via meta-analysis.
Neurological Manifestations of SARS-CoV-2 Infection: Protocol for a Sub-analysis of the COVID-19 Critical Care Consortium Observational Study
Neurological manifestations and complications in coronavirus disease-2019 (COVID-19) patients are frequent. Prior studies suggested a possible association between neurological complications and fatal outcome, as well as the existence of potential modifiable risk factors associated to their occurrence. Therefore, more information is needed regarding the incidence and type of neurological complications, risk factors, and associated outcomes in COVID-19.
Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study
To identify patient-level parameters, readily available at the bedside, associated with the risk of in-hospital mortality within 28 days from commencement of invasive mechanical ventilation or coronavirus disease 2019.
Early short course of neuromuscular blocking agents in patients with COVID-19 ARDS: a propensity score analysis
The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate in COVID-19 patients with moderate-to-severe ARDS the impact of early use of NMBAs on 90-day mortality, through propensity score (PS) matching analysis.
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure
Martin Urner, Adrian G Barnett, Gianluigi Li Bassi, Daniel Brodie, Heidi Dalton, Niall D Ferguson, Silver Heinsar, Carol L Hodgson, Giles Peek, Kiran Shekar, Jacky Y Suen, John F Fraser, Eddy Fan on behalf of the COVID-19 Critical Care Consortium Investigators. http://dx.doi.org/10.1136/ bmj-2021-068723
Non-Invasive Multimodal Neuromonitoring in Non-Critically Ill Hospitalized Adult Patients With COVID-19: A Systematic Review and Meta-Analysis
Denise Battaglini, Lavienraj Premraj, Samuel Huth, Jonathon Fanning, Glenn Whitman, Rakesh C. Arora, Judith Bellapart, Diego Bastos Porto, Fabio Silvio Taccone, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Rafael Badenes, Sung-Min Cho, Chiara Robba, and the COVID-19 Critical Care Consortium.
Impact of renin–angiotensin–aldosterone system inhibition on mortality in critically ill COVID-19 patients with pre-existing hypertension: a prospective cohort study
Kei Sato, Nicole White, Jonathon P. Fanning, Nchafatso Obonyo, Michael H. Yamashita, Vinesh Appadurai, Anna Ciullo , Meryta May, Elliott T. Worku, Leticia Helms, Shinichiro Ohshimo, Dafsah A. Juzar, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, and Rakesh C. Arora on behalf of COVID-19 Critical Care Consortium Investigators.
Prone Position during Venovenous Extracorporeal Membrane Oxygenation for COVID-19
Akram M Zaaqoq, MD, MPH; Adrian G Barnett, PhD; Matthew J Griffee, MD ; Graeme MacLaren, MD, MSc; Jeffrey P. Jacobs, MD; Silver Heinsar, MD; Jacky Y Suen, PhD; Gianluigi Li Bassi, MD, PhD; John F Fraser, MD, PhD; Heidi J Dalton, MD; Giles J Peek, MD, on behalf of the COVID-19 Critical Care Consortium Investigators.
Stroke complicating critically ill patients with SARS-CoV-2: Analysis of the COVID-19 Critical Care Consortium (CCCC) international, multicenter observational study
Jonathon Fanning, BSc, MBBS, Ph.D., FANZCA, FCICM, Adrian Barnett, BSc, Ph.D., Lavien Premraj, BMSc, Glenn Whitman, M.D., Rakesh Arora, MD, Denise Battaglini, M.D., Samuel Huth, BSc, Diego Bastos Porto, M.D., MSc, HuiMahn Alex Choi, M.D., MS, Jacky Suen, BSc, Ph.D., Gianluigi Li Bassi, M.D., Ph.D., John Fraser, MBBS, Ph.D., FRCP, FRCA, FFARCSI, FCICM, Matthew Griffee, M.D., Chiara Robba, M.D., Ph.D., Sung-Min Cho, DO, MHS, on behalf of the COVID-19 Critical Care Consortium Investigators.
Characteristics and Outcomes of Patients with COVID-19 Admitted to Intensive Care Units – A Report from the Global COVID-19 Critical Care Consortium
Pauline Yeung Ng, MBBS; Heidi J Dalton, MD, MCCM; Nicole White, PhD; John F Fraser, MBChB, PhD, FRCP(Glas), FFARCSI, FRCA, FCICM, on behalf of the COVID-19 Critical Care Consortium.
Mobile Extracorporeal Membrane Oxygenation for Covid-19 Does Not Pose Extra Risk to Transport Team
Previous experience has shown that transporting patients on extracorporeal membrane oxygenation (ECMO) is a safe and effective mode of transferring critically ill patients requiring maximum mechanical ventilator support to a quaternary care center. The coronavirus disease 2019 (COVID-19) pandemic posed new challenges. This is a multicenter, retrospective study of 113 patients with confirmed severe acute respiratory syndrome coronavirus 2, cannulated at an outside hospital and transported on ECMO to an ECMO center.
Beneficial Effect of Prone Positioning During Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019
The study investigated the impact of prone positioning during venovenous extracorporeal membrane oxygenation support for coronavirus disease 2019 acute respiratory failure on the patient outcome. Our study highlights that prone positioning during venovenous extracorporeal membrane
oxygenation support for refractory coronavirus disease
2019-related acute respiratory distress syndrome is associated
with reduced mortality.
Neurological Manifestations of Coronavirus Disease 2019: A Comprehensive Review and Meta-Analysis of the First 6 Months of Pandemic Reporting
There is growing evidence that SARS-Cov-2 infection is associated with severe neurological complications. Understanding the nature and prevalence of these neurologic manifestations is essential for identifying higher-risk patients and projecting demand for ongoing resource utilisation. This review and meta-analysis report the neurologic manifestations identified in hospitalised COVID-19 patients and provide a preliminary estimate of disease prevalence.
Ischemic and Hemorrhagic Stroke Among Critically Ill Patients With Coronavirus Disease 2019: An International Multicenter Coronavirus Disease 2019 Critical Care Consortium Study
The COVID-19 Critical Care Consortium Neurology Sub-Study paper exploring prevalence & outcomes of acute stroke in an international cohort of patients with COVID-19 requiring ICU admission.
COVID‑19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study.
The ISARIC collaboration has allowed reporting of reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
Ethical factors determining ECMO allocation during the COVID-19 pandemic.
ECMO is a particularly scarce resource during the COVID-19 pandemic. Its allocation involves ethical considerations that may be different to usual times. There is limited pre-pandemic literature on the ethical factors that ECMO physicians consider during ECMO allocation. We report the results of a small international exploratory survey of ECMO clinicians' views on different patient factors in ECMO decision-making prior to and during the COVID-19 pandemic.
An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients
In the early stage of the pandemic, two distinct clinical phenotypes of COVID-19 respiratory disease were postulated, differing in respiratory system compliance. The COVID-19 CCC provides novel insights on this crucial parameter overcoming previous stratifications.
Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study.
There is a paucity of data that can be used to guide the management of critically ill patients with COVID-19. In response, a research and data-sharing collaborative-The COVID-19 Critical Care Consortium-has been assembled to harness the cumulative experience of intensive care units (ICUs) worldwide. The resulting observational study provides a platform to rapidly disseminate detailed data and insights crucial to improving outcomes.