Acute Kidney Injury Sub-Study
Acute Kidney Injury (AKI) and Acute Respiratory Distress Syndrome (ARDS) are closely linked condition seen in the critically ill. AKI rates of 25-60% in mechanically ventilated patients with ARF/ARDS, and AKI in this population substantially reduces survival. In the LUNG SAFE cohort AKI was seen in 39% of patients within 1 day ARDS diagnosis of ARDS. Of concern even modest elevations in creatinine was associated with worsened outcome, with hospital mortality increasing from 31% in patients with no AKI to 50% in mild- moderate AKI, and 58% in severe AKI.
The COVID-Critical study is an excellent opportunity to determine the incidence and severity of COVID-induced AKI, the impact of renal dysfunction severity, critical care management (e.g. mechanical ventilation, fluids, nephrotoxic drugs), the extent of recovery of renal function, and outcomes from COVID-19 critical illness.
This sub-study of the international COVID-19 Critical Care Consortium will enrol patients (prospectively and retrospectively) developing AKI as defined by AKIN/KDIGO network criteria during CVID-19 critical illness. It will determine influence of altered coagulation on AKI incidence and severity, the effect of MV modalities (PEEP, Proning, Neuromuscular blockade) on COVID-19 induced AKI, the outcomes of AKI in in patients with COVID-19 AHRF/ARDS.
Inclusion Criteria
As for ECMOCARD Study patients
In patients in whom mild AKI develops (serum creatinine rise >20% from baseline; or upper normal level where no evidence of CRF), eCRF automatically guides site investigator to page to join the AKI sub-study characterise these patients.
How to get involved
1. If you are interested in participating in this sub-study please contact the Principal Investigator:
John Laffey john.laffey@nuigalway.ie
2. You will need to submit the COVID Critical Protocol to your IRB for approval. The protocol is available here.
3. Email your IRB approval/amendment document to ECMOCARD@health.qld.gov.au and we will arrange REDCap access to the sub-study fields.
Last Updated April 28, 2021